Important note: sign-up for NURSING (VPK), CHEMISTRY (C) and ELECTRICAL & ELECTRONIC ENGINEERING (ET) students use Bisoncode: L.24635
Important note: sign-up for BIOLOGY & LABORATORY RESEARCH (BML) students use Bisoncode: L.26623

 

You will be helping in the development of an organ-on-a-chip device that allows us to do toxicity testing of drugs, which is now done with animal testing. The project requires an enormous range of disciplines to make this happen. Are you going to join us. Be part of this team effort!!! 

Drug development at present is a very expensive and inefficient process, which is largely due to the dependence on preclinical tests with animals that cannot fully capture human physiological responses. As an example, it takes an estimated 10-15 years and $5 billion to bring a new drug to the market. $ 3.2 billion of this is spent on preclinical research and development phases, involving experiments using a large number of animal models and animal-derived cell lines. However, animal tests cannot accurately predict how the human organ and body will respond to a new drug because of the inherent differences between human and animal physiology. More than 30% of drug formulations that look promising during preclinical (animal) studies end up being toxic to humans and fail human clinical trials. 

The human heart is of particular interest as one-fourth of the drug formulations that fail are related to heart diseases. According to statistical data, cardiac diseases are the most common causes of death of humans around the world. In most cases, heart transplantation is the only way to treat patients. However, the lack of a donor and the response of the immune system preclude the treatment in a huge number of clinical cases. 

Organ-on-a-chip technology utilizing true human cells cultured in perfused microfluidic devices holds great promise to revolutionize pharmaceutical drug testing for heart-related diseases and personalized therapy in the context of precision medicine’. In particular, it is anticipated that organ-on-a-chip technology can substantially replace animal models for drug testing and will enable more predictive, cheaper and more reliable (standardized) assays for biomedical science and drug testing. 

The main goal of this project is to fabricate a simple heart-on-a-chip demonstrator device according to the start of the art and carry out drug testing with the device.  

Required study programs:

Chemistry (C): Studying effects of medicine on living heart cells

Biology and Laboratory Research (BML): Development of a device which hosts living cells

Electrical and Electronic Engineering (ET): Hosts living cells from which signals are measured and extracted

Nursing (VPK): Research tp improve treatment efficacy of medicines

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Questions about this project?

Feel free to contact us if you have any questions about this project. You can call us at 088 - 019 53 11 or use the form below. We wil get back to you within two business days.