To sign up for this cluster, use Bison code L.27340.
Important note: students G&T (Health and Applied Technology) use L.27341.
This cluster consists of the following projects:
COVIDSENS – Rapid COVID-19 Detection with Photonic Biosensors
In recent years, there have been several examples of serious virus outbreaks such as severe acute respiratory syndrome (SARS) and most recently coronavirus disease 2019 (COVID-19). These virus outbreaks can rapidly spread worldwide to become pandemics with devastating effects on populations and their social and economic development. Therefore, fast, on-site, and sensitive detection of viruses is essential in detecting the onset of viral epidemics and preventing their spread. Current virus detection methods, mainly based on polymerase chain reaction (PCR), are not compatible with point-of-care (POC) settings as they are time-consuming, expensive and require labor-intensive sample preparation and trained personnel for their operation. Lab-on-a-Chip (LOC) photonic biosensors are a good candidate for sensitive, rapid and multiplex detection of various analytes such as micro-organisms (viruses and bacteria) and biomarkers (proteins and DNA/RNA molecules). The high sensitivity that photonic biosensors can achieve could result to less sample pre-concentration handling, which contributes to faster analysis and savings on operational costs. Moreover, these biosensors are easy-to-use and compact, offering the possibility for development of portable/handheld devices. In this project, we are working in collaboration with several hightech SME companies and other relevant partners, towards the realization of a portable demonstrator for rapid, sensitive detection of coronavirus, based on a multichannel photonic biosensor prototype. This will be achieved by integrating existing innovative technologies such as lab-on-a-chip, microfluidics, inkjet printing and integrated photonic sensors. This portable demonstrator with be a first step towards development of a handheld device to rapidly detect coronavirus at POC settings, such as airports. The developed demonstrator, consisting of LOC system and read-out detector, will be first tested with standard/spiked samples, calibrated and evaluated with complex (patient) samples, e.g. serum, and benchmarked with gold standard methods. Furthermore it will be investigated how this demonstrator can be applied for rapid (corona-)virus detection at POC settings to prevent outbreaks becoming pandemics. In this project you will be contributing to the development of a portable demonstrator based on existing photonic biosensor prototypes and its validation with clinically relevant (patient) samples. Next to COVIDSENS project, NanoBio is also applying photonic biosensors in DIASENS project for the diagnosis of diabetes at an early stage by sensitive and reliable detection of insuline in patient samples. Furthermore, in PHOBIOSENS project we are working on development of a portable demonstrator that enables rapid, easy and multiplexed detection of antibiotics in milk based on a multichannel photonic biosensor principle.
The GENIE app – an end-of-life conversation guide for people at risk for COVID-19
The physical condition of those people who are suffering from COVID-19 can deteriorate unexpectedly and very quickly. They can reach such a vulnerable and life-threatening condition, that carers and professionals are obliged to make treatment choices without patient consultation and patient consent. This is primarily applicable for people aged 70 years and older and those already diagnosed with chronic conditions such as COPD, heart failure and obesity.
Advanced discussions about needs and wishes in end-of-life care can prevent en reduce high stress-levels for carers as well as for patients themselves. In this ‘current COVID-19 society’, communication and discussion is urgent before getting the COVID-19 infection, especially for those people at- risk.
However, COVID-19 infected persons as well as their loved ones frequently do not know what to expect of the further illness-trajectory. Especially those people with lower levels of literacy and lower Social-Economic Status (SES) have less capability of expressing their needs and wishes and have less access to healthcare. For these people and their health professionals, we have started the GENIE project. To tailor the GENIE app to the target group of people at-risk of COVID-19 and their healthcare professionals, we hope students will help us study user requirements, user experience design (testing and validating the app with target groups), design and marketing for the GENIE app.
NB: data-collection could be adapted to ‘Corona-proof’ methods, such as digital validation rounds with end-users
The challenges of the 1.5 meter society
The challenges formed by Covid-19 are real for a lot of companies. New rules to open and new forms for your hospitality. As a catering company, you would like to open. But how do you apply these rules without sacrificing hospitality?
The municipality thinks along with its companies. Terraces are expanded, allowing guests to keep the required distance.
The city is also thinking about how to create a hospitable city center within this new society, as the question arises: How can you remain a hospitable city?
A lot of questions. So lets learn from each other by sharing what works (and what doesn’t). In this assignment, you will look for the companies in Deventer which are changing and learning (in the catering industry, office environments and more). How is everyone dealing with these new measures? How do we join forces so that we can create a hospitable city center with pleasant working environments within the new 1,5 meter society?
You will collaborate with DeventerMarketing, Catering companies, Stiching Deventer Binnenstad management, and the municipality.
Collect hospitable examples in the city and create a way to share this. Then come up with new ideas for creating a hospitable city center.
Deep UV disinfection cabinet
Van Remmen UV Technology is the supplier of Europe’s most sustainable UV disinfection systems. A unique approach and great passion for what we do is the power of our company. We look ahead and think in solutions. We test and validate our UV equipment with micro organisms, to be sure that our systems do what they are supposed to. Sustainability has a high priority within our company. Based on this core belief, we develop the most energy efficient systems in the business.
Van Remmen has developed a disinfection cabinet called DeepUV™ aimed at disinfecting mouth masks and other medical equipment. The cabinet combines various UV lights to facilitate multiple disinfecting mechanisms from deep oxidation with ozon to supperficial sterilisation with UV-C in order to provide a thourough biological and chemical cleaning of the products.
An interesting test case which we also applied on real corona proof mouth masks in collaboration with the Isala hospital. Since the hospital market is using and will be using mainly single use products, the challenge becomes how this interesting new instrument could possibly be applied to new end markets.
Van Remmen would therefore like to stimulate Saxion students from various backgrounds to come up with new applications for this disinfection cabinet. Research will need to be done into new markets with specific requirements for the product.
The DeepUV™ cabinet can be used by Saxion, under the condition that knowledge is being shared and the Intellectual Property remains with Van Remmen.
Following directions for research are inspirational and can be adjusted based on the project group.
Market research; which markets and applications are fitting to this products, which products are interesting
Design; Improvements options, ideal product configuration; adjustments for market diversification, integration of new techniques
Operation; Ozon production, penetration of UV and Ozon, by products, aging effects.
Validation; how to test functionality, which testing standards are applicable, what are the differences between markets/applications
Commercial; what business models can be based upon this, what is the best translation from prototype to production model at realistic costs?
Automatisation and processes; automising, security, relevant programs
Impact; footprint research, risks, dangers and securities
Ideas/examples of possible end markets:
Sterilisation sluice in cleanroom/clinical/food applications; Desmelling and re-cleaning of demonstration products (clothing); Tattoo and beauty branche, many contact ; Doctors and dentists; Sterilisation sluice for international packaging and mail; Aging testing of paint and polymers, hardening of resins; Re-using consumables and medical single use products in times of crisis.
Questions about this cluster?
Feel free to contact us if you have any questions about this cluster. You can call us at 088 - 019 53 11 or use the form below. We wil get back to you within two business days.